Grape Seeds Counter Colon Cancer

The super fruit is at it again.


Grape seed extract, along with chemotherapy, was found to fight colorectal cancer and protect the intestines during treatment, according to a study by University of Adelaide Professor Dr. Gordon Howarth published earlier this year in medical journal “Plos One”.


“Our research … showed that in laboratory studies grape seed taken orally significantly reduced inflammation and tissue damage caused by chemotherapy in the small intestine, and had no harmful effects on non-cancerous cells,” researcher and study spokesperson Dr. Amy Cheah told the University of Adelaide in a press release earlier this year. ” Unlike chemotherapy, grape seed appears to selectively act on cancer cells and leave healthy cells almost unaffected.”


Up until this study by Cheah and her colleagues, grape seeds effect in colon cancer treatment were unknown.


“This is the first study showing that grape seed  can enhance the potency of one of the major chemotherapy drugs in its action against colon cancer cells,” Cheah said in the release.


Cheah and her team took commercially available grape seed extract, extracted the tannins and then freeze-dried the tannins. Once frozen, the tannins were powdered and used in the laboratory on colon cancer cells, according to the press release.

The results were very encouraging. The grape seed extract “showed no side effects on the healthy intestine at concentrations of up to 1000mg/kg”. The extract also “decreased chemotherapy-induced inflammation by up to 55 percent” and “increased growth inhibitory effects of chemotherapy on colon cancer cells in culture by 26 percent.”


When research began, Cheah and her colleagues were skeptical about the extracts interaction with chemotherapy.


“We were initially concerned that grape seed could reduce the effectiveness of the chemotherapy,” Cheah said. 


The team’s skepticism eventually shifted to satisfaction. 


“In contrast, we found that grape seed extract not only aided the ability of chemotherapy to kill cancer cells, but was also more potent than the chemotherapy we tested at one concentration,” Cheah said in the press release. 


The tests took place in a laboratory with colon cancer cells grown in culture. The grape seed extract/chemotherapy combination was not tested on humans with colorectal cancer. However, team leader Howarth told the University of Adelaide he believes their study is the first step in using the extract as an effective means of  fighting cancer.


“Grape seed is showing great potential,” he said in the university’s release. “These first anti-cancer results are from cell culture and the next step will be to investigate more widely.”


According to medical website Newsmaxhealth, the extract is relatively new to the United States but has been used in Europe for various ailments.


“Research has shown that it is beneficial for a number of heart conditions,” Newsmaxhealth reported. “The supplement has also been used to treat chronic venous insufficiency.”


The website noted, however, that “it is impossible to get the levels of (benefits) in grape seed oil from drinking wine.”


By: Snooth – Articles


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